A New Resorcinol Derivative from the Bark of Aegiceras Floridum (Primulaceae)

Tiến sĩNguyễn Hữu HùngHuynh-Van-Long Luu, Thi-Hoai-Thu Nguyen, Kim-Phi-Phung Nguyen, Ngoc-Hong Nguyen, Thuc-Huy Duong

Khoa Công Nghệ

Thể loại: Bài báo

Sơ lược nội dung

Chemical investigation of the Vietnamese plant Aegiceras floridum Roem. & Schult. (Primulaceae) led to the isolation of the new compound 3-methoxy-5-nonylphenol (1) along with five known ones 2,8,10-trihydroxy-6H-benzo[c]chromen-6-one (2), 2-hydroxy-5-methoxy-3-nonylbenzo-1,4-quinone (3), 5-(3-hydroxypropyl)-7-methoxy-3-(methylbenzofuran-2-yl)-3-methoxyphenol (4), 2,8-dihydroxy-7-methoxy-3,9-diundecyldibenzofuran-1,4-dione (5) and 10-hydroxy-4-methoxy-2,11-diundecylgomphilactone (6). The structures were elucidated by analysis of their HRESIMS and NMR data as well as the comparison of their NMR data with those reported in the literature. The cytotoxic activity of selected isolated compounds against some cancer cell lines such as human epithelial carcinoma (HeLa), human lung cancer (NCI-H460), liver hepatocellular carcinoma (HepG2), human breast cancer (MCF-7), and acute T cell leukemia (Jurkat) was evaluated. Among them, 3 showed moderate activities against MCF-7 with an IC50 of 17.77 µM and NCI-H460 with an IC50 of 25.02 µM. The result of DPPH radical scavenging activity assay indicated that compounds 2–4 and 6 revealed weak antioxidant activity.

Thông tin chung
Thể loại
Bài báo
Năm xuất bản
01 Thg12 2020
Ngôn ngữ gốc
Tiếng Anh
Tạp chí công bố
Natural Product Research
Loại tạp chí
Danh mục ISI/Scopus
1478-6419 | 1478-6427
Chất lượng

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