New triterpene sulfates from Vietnamese red alga Tricleocarpa fragilis and their α-glucosidase inhibitory activity
PhD.Bui Thi Phuong ThuyThi Van Anh Tran, Van Minh Nguyen, Thi Ai Nhung Nguyen, Dat Huy Thanh Nguyen, Duy Hien Tran, Van Tat Pham, The Han Nguyen
Faculty of Fundamental Sciences
Research output: Article
Three new compounds (methyl-3β,25-dihydroxycycloart-23-en-29-oate 3-sulfate (1), methyl-3β-hydroxy-25-methoxycycloart-23-en-29-oate 3-sulfate (2) and 3β-hydroxy-25-methoxycycloart-23-ene 3-sulfate (3)) and a known one (3β-hydroxycycloart-24-en-23-one 3-sulfate (4)) were isolated from Vietnamese red alga Tricleocarpa fragilis. All isolated compounds 1-4 showed potent inhibitory activity against yeast α-glucosidase with IC50 values of 16.62 ± 2.80, 36.34 ± 4.04, 30.19 ± 5.01 and 6.52 ± 0.17 µM, respectively. The docking data showed that the substitutions at C-3 and the differences in the side chain of cycloartane-skeleton could influence the interaction of molecule with enzyme, which was consistent with the experimental findings.
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